KMID : 0043319970200030264
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Archives of Pharmacal Research 1997 Volume.20 No. 3 p.264 ~ p.268
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Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives
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Cho Won-Jea
Yoo Su-Jeong Park Myun-Ji Chung Byung-Ho Lee Chong-Ock
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Abstract
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In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.
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KEYWORD
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Antitumor activity, 3-Arylisoquinoline derivatives
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